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Translating the pharmacology of dual GLP-1/GIP agonists into actionable preclinical data requires tools capable of detecting receptor engagement with cellular and spatial resolution , challenging because GLP-1R and GIPR are low-abundance membrane proteins, and no reliable commercial antibody exists for GIPR detection in primary tissues
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Small, consistent data points guide safer, more sustainable outcomes
Heart health: Early research suggests that both drugs may have some heart benefits, but more studies are needed to fully understand how they affect heart health in the long term
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