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96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis
If you really cant bear the dry mouth, insomnia, or headaches, then you may have to stop taking Qsymia and try another medication, but you need to consult with your healthcare provider before stopping the medication
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