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Oral supplements require intrinsic factor for absorption, and many people (especially those over 50) have reduced absorption capacity

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Vitamin B12 is vital to our bodies, as it plays a specific role in helping the brain to function while the production of our DNA and red blood cells are being created, it can also be effective for individuals who lead what is considered a clean lifestyle like vegan or vegetarian diets, this is because they are not getting enough natural vitamin B12 in their diets from the foods which are regularly eaten

Kallmans Syndrome) or result from local tissue destruction from a pituitary tumor or prior surgery/radiation to the area