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What did Triumph-3 show

Orlistat causes different side effects related to its mechanism of reducing fat absorption: Oily spotting and flatulence Urgent bowel movements and faecal incontinence Oily or fatty stools These effects are typically worse when consuming high-fat meals and can be socially distressing

Results: The 18-month risk for ION was 8.5 versus 5.5 per 10 000 among GLP-1RA users versus SGLT2i users (RD, 3.0 [95% CI, 0.4 to 5.7]) and 7.8 versus 4.2 per 10 000 among GLP-1RA users versus DPP4i users (RD, 3.6 [CI, 1.1 to 6.1])

A brief discussion of common causes of hyperkalemia related to CKD and diabetes and their mechanisms is presented in what follows