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However, it is unclear why the aggregation of GST fusion proteins increases under specific circumstances
-endorphin, the POMC-derived opioid peptide, has the capacity to upregulate melanogenesis and melanin distribution by promoting maturation of melanocytes and arborisation of their dendritic processes, thus increasing the efficacy of the transfer and distribution of melanosomes to neighbouring keratinocytes [23, 29]
Wilson RB, Lathigara D, Kaushal D
Even in this narrow population, a provider must weigh adding a second agent against switching to the more potent dual-mechanism drug or optimizing current therapy
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