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Many GLP-1 boosting supplements contain prebiotic fiber that promotes SCFA production (like butyrate), which can stimulate GLP-1 release in the colon

And the review doesnt show that berberine can be applied on a patch and absorbed through the bloodstream, Jay adds

Rapid pharmacologically induced weight reduction may be accompanied by losses of lean mass, particularly when energy deficits are large, protein intake is inadequate, and resistance exercise is not implemented

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