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Pogacnik T, Zmitek J, Hristo H, Kersmanc P, Butina MR, Zmitek K
Fasted administration maximizes the GH response because elevated insulin from a recent meal suppresses GH secretion
A separate study showed that methylprednisolone did not block ipamorelin's GH-releasing effect despite suppressing endogenous GH secretion, demonstrating that the GHS-R1a pathway can override glucocorticoid-mediated GH suppression
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