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However, repeated administration of GHRP has been reported to desensitize its stimulatory effect on GH secretion, and there have been no studies of the growth promoting effect after its long-term use, thereby limiting clinical application.21 In our study, oral administration of 4 mg/kg of MK-677 increased the peak concentrations of serum GH by 1.8-fold, compared to basal levels, and GH AUC was significantly increased, suggesting that oral administration of MK-677 has GH-releasing activity

Lilly argued the Cmax reduction was of limited clinical relevance because AUC drives contraceptive efficacy

Participants tolerated the peptide well, with injection site reactions being the most common side effect

Ciccia, A