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The EMAs safety committee has issued a warning that the GLP-1 receptor agonist Ozempic (semaglutide, Novo Nordisk A/S) can cause an acute eye condition in which the optic nerve is damaged by a sudden loss of blood supply

A reconstituted peptide runs on two clocks at once, and the shorter one always wins

USA 118 , e2021096118 (2021)

The latest research tells a pretty simple story: GLP1 drugs can lean on your bones during weight loss, but exercise and smart planning give you a lot of that strength back. What The GLP1 + Exercise Trial Actually Showed In a JAMA trial, adults with obesity first went through an 8week lowcalorie diet, then moved into one of four paths for a year: exercise alone, a GLP1 drug alone (liraglutide), both together, or placebo. The GLP1only group lost weight but also lost bone density at the hip and spine compared with placebo or exercise alone. The combo group exercise plus GLP1 lost even more weight but preserved bone density at the hip, spine, and forearm. TL;DR: Exercise does not sit behind the prescription