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Reduced caloric intake and digestion One reason Mounjaro may increase feelings of cold is due to reduced food intake, which affects body heat production

To avoid muscle mass by GLP-1 analogs, combination therapy of muscle mass inducer such as Bimagrumab (Anti-ACVR2B Antibody) [54] with GLP-1 analogs would be a good treatment regimen to suppress muscle mass reduction leads to sarcopenia

This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested

Adding tesamorelin may provide incremental benefits for visceral fat and muscle preservation, but those benefits come with significant unknown risks