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Importantly, the relevance of these findings to humans remains uncertain , as rodents are known to be particularly susceptible to GLP-1 receptor agonist-induced thyroid C-cell proliferation, and no causal relationship has been established in human clinical trials or post-marketing surveillance

The only way to increase carnitine in muscle is very prolonged carnitine supplementation in conjunction with a very high carbohydrate load or any other feeding that produces high insulin levels

Without adequate carnitine, fatty acids cannot enter the mitochondria efficiently, and fat oxidation is impaired