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Hogan et al

doi:10.2353/ajpath.2008.080119

NAC serves as a precursor for glutathione (GSH) synthesis, a critical antioxidant that neutralizes ROS and protects cells from lipid peroxidation

Overexpression of HK2 not only accelerates glucose uptake, but also activates multiple pathways required for glucose influx into Kras-driven PC growth, including the pentose phosphate pathway, serine synthesis pathway, and hexosamine biosynthesis pathway, which protomes the proliferation, invasion, and metastasis of PC (46, 47)