Published research has explored its role in promoting angiogenesis (new blood vessel formation), upregulating VEGF (vascular endothelial growth factor), stimulating fibroblast migration and collagen deposition, modulating nitric oxide pathways, and protecting the gastrointestinal lining
A small uncontrolled open-label trial reported that receiving 120 mg pine bark extract, 60 mg vitamin C, and 30 IU vitamin E daily for 3 months in migraine patients led to a significant reduction in the headache frequency, severity, and migraine disability (91)
If so, you may be noticing facial changes
The basic process is to start with an introductory dose of 2.5 mg, continue for 4 weeks to check for side effects, and then switch to a maintenance dose of 5mg