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Initial research typically viewed the liver as the main location where metformin exerts its control over glucose production, utilizing both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent pathways
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According to NICE guidance, GLP-1 receptor agonists for type 2 diabetes (NG28) are recommended when other treatments have not achieved adequate glycaemic control
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Intramuscular injections typically target the deltoid or gluteal muscles
On average, tirzepatide led to a superior weight loss of 20.2% compared to 13.7% with semaglutide
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