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Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures
Normally distributed continuous variables were reported as the mean SD, and non-normally distributed continuous variables were expressed as the median and interquartile range
The key findings were: The highest dose group (12mg) lost an average of 24.2% of body weight over 48 weeks Participants with type 2 diabetes lost 17.5% over 36 weeks Reductions in waist circumference, blood pressure, triglycerides, and fasting glucose were all statistically significant Side effects were mostly gastrointestinal and dose-dependent Phase 3 trials are ongoing
Importantly, L2-Cmu treatment in females did not adversely affect cardiac function, but instead restored diastolic function to more youthful levels (Fig
