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FIGURE 3 Anabolic signaling pathways after acute infusion of oIGF-1 Phosphorylation of Akt (Ser 473) and Erk 1/2 (Thr 202/Tyr 204) (Figure 4) increased by 40-fold and 16-fold, respectively, in skeletal muscle from 0 to 15 min of infusion of oIGF-1 at 220 g h 1 compared to animals that received a saline infusion