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Originally termed Stein-Leventhal syndrome, PCOS represents a multisystem disorder characterized by intricate associations with metabolic dysregulation and hypothalamic-pituitary-ovarian axis (HPOA) dysfunction, posing substantial threats to fertility during womens prime reproductive years ( PCOS typically manifests during adolescence and is diagnostically characterized by three main features: namely long-term ovulatory dysfunction, hyperandrogenism (HA), and polycystic ovarian morphology, which form the basis of the diagnostic criteria for PCOS ( Current clinical practice recognizes that there is no one-size-fits-all therapeutic approach for PCOS management
Acta Pharm Sin B 11:23622395 Cao J, Li X, Tian H (2020) Metal-organic framework (MOF)-based drug delivery
suggest that these abnormalities may play roles in causing arrest of the embryos
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