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Figure 2 5 Trained immunity of inflammatory diseases 5.1 Autoimmune diseases 5.1.1 Sarcoidosis Sarcoidosis is a non-caseating epithelioid granulomatous inflammatory disease, the formation of these granulomas disrupts tissue homeostasis, primarily affecting the lung parenchyma and leading to clinical symptoms such as cough and dyspnea, Multiple organ involvement (39)

TNF is a crucial mediator of this pathology. TNF and another pro-inflammatory substance called interleukin 1, produce products like reactive oxygen species that damage both the filters and the elastic cells that wrap around their exterior

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interquartile range: 3.629.52 vs