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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
30-53% of new cases are directly linked to obesity
C., Kriegesmann, J., Dowman, L
Regular monitoring of blood glucose, weight, gastrointestinal tolerance, and injection technique ensures safe use and enables timely dose modifications based on individual response and biomarker trends
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