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That transient volume contraction, combined with NSAID-mediated renal vasoconstriction, raises the risk of acute kidney injury, particularly in patients who already carry chronic kidney disease, hypertension, or are over 60

Additionally, osteocalcin, a bone-derived hormone, has been shown to alleviate neuronal loss in acute ischemic stroke by inhibiting prolyl hydroxylase domain-containing protein 1(PHD1) and preventing the degradation of gasdermin D, thereby improving prognosis (59)