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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

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This occurs through several potential mechanisms: IGF-1 stimulates collagen synthesis and cartilage matrix expansion Growth signalling in synovial tissue may increase fluid production Systemic effects on sodium and water handling This side effect is typically mild and reversible